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Table 2 Expected frequency of amino acid replacement changes

From: Mutational pattern and frequency of induced nucleotide changes in mouse ENU mutagenesis

  To
From Ala Arg Asn Asp Cys Gln Glu Gly His Ile Leu Lys Met Phe Pro Ser Thr Trp Tyr Val X Total
Ala *    4.4    2.1 0.0        1.0 6.3 14.6    19.7   48.3
Arg   *    4.1 3.6   6.2 3.0 1.1 2.8 5.0 1.1   0.5 4.3 0.4 4.4    3.3 39.7
Asn    * 9.5      1.1 4.2   7.6     9.5 1.1   4.2    37.0
Asp 1.4   10.1 *    10.3 12.5 0.7           4.3 5.5   44.9
Cys   10.1    *    1.6       2.1   7.2   0.8 4.9   4.4 31.2
Gln   12.0     * 0.0   5.3   5.3 4.4    1.3       13.1 41.5
Glu 1.9    8.2   1.0 * 17.5     14.2         7.8 6.1 56.7
Gly 1.0 7.8   7.0 3.0   6.8 *         7.0   1.4   5.9 1.5 41.6
His   6.7 2.4 0.0   5.2    *   3.0     0.7     7.3    25.4
Ile   0.5 11.4        * 2.2 2.1 3.0 4.5   2.7 19.9    11.9   58.0
Leu   5.7     14.2    9.9 5.9 *   7.7 11.9 35.6 8.7   0.9   1.4 6.3 108.3
Lys   14.6 6.8    1.6 14.6    2.5   * 4.0     1.6     6.5 52.2
Met   1.6         7.3 3.3 6.8 *     10.0    6.0   35.1
Phe      2.8      11.6 25.4    *   17.1    11.6 2.8   71.1
Pro 0.0 0.0     2.2    3.5   17.2     * 17.2 5.7      45.8
Ser 3.5 7.4 6.8   3.7    8.4   2.9 4.5    9.8 21.9 * 15.3 0.0 3.3   1.5 89.1
Thr 14.2 0.0 3.1        13.9   2.1 1.6   1.6 6.3 *      42.9
Trp   9.1    1.3    0.9    1.1      0.2   *    5.2 17.8
Tyr    8.4 2.0 7.4     12.4      3.3   0.8    *   6.0 40.4
Val 27.3    7.8    10.7 4.4   7.1 4.2   6.1 2.4       *   70.0
X   0.9    0.2 0.6 0.1 0.1    0.3 0.4     0.1   0.5 0.2   * 3.2
Total 49.4 76.5 49.0 38.8 22.5 28.5 44.7 51.6 35.9 56.5 69.4 42.5 23.5 33.9 62.7 87.3 68.6 8.0 35.7 61.0 54.0 1000.0
  1. Frequencies are adjusted so as to give the expected number of changes per 1,000 nonsynonymous mutations. Blanks correspond to amino acid replacements that require multiple mutational steps. An X designates termination codons, whereas asterisks (*) indicate synonymous changes.