BMC Molecular Biology

Table 2 Expected frequency of amino acid replacement changes

From: Mutational pattern and frequency of induced nucleotide changes in mouse ENU mutagenesis

	To
From	Ala	Arg	Asn	Asp	Cys	Gln	Glu	Gly	His	Ile	Leu	Lys	Met	Phe	Pro	Ser	Thr	Trp	Tyr	Val	X	Total
Ala	*			4.4			2.1	0.0							1.0	6.3	14.6			19.7		48.3
Arg		*			4.1	3.6		6.2	3.0	1.1	2.8	5.0	1.1		0.5	4.3	0.4	4.4			3.3	39.7
Asn			*	9.5					1.1	4.2		7.6				9.5	1.1		4.2			37.0
Asp	1.4		10.1	*			10.3	12.5	0.7										4.3	5.5		44.9
Cys		10.1			*			1.6						2.1		7.2		0.8	4.9		4.4	31.2
Gln		12.0				*	0.0		5.3		5.3	4.4			1.3						13.1	41.5
Glu	1.9			8.2		1.0	*	17.5				14.2								7.8	6.1	56.7
Gly	1.0	7.8		7.0	3.0		6.8	*								7.0		1.4		5.9	1.5	41.6
His		6.7	2.4	0.0		5.2			*		3.0				0.7				7.3			25.4
Ile		0.5	11.4							*	2.2	2.1	3.0	4.5		2.7	19.9			11.9		58.0
Leu		5.7				14.2			9.9	5.9	*		7.7	11.9	35.6	8.7		0.9		1.4	6.3	108.3
Lys		14.6	6.8			1.6	14.6			2.5		*	4.0				1.6				6.5	52.2
Met		1.6								7.3	3.3	6.8	*				10.0			6.0		35.1
Phe					2.8					11.6	25.4			*		17.1			11.6	2.8		71.1
Pro	0.0	0.0				2.2			3.5		17.2				*	17.2	5.7					45.8
Ser	3.5	7.4	6.8		3.7			8.4		2.9	4.5			9.8	21.9	*	15.3	0.0	3.3		1.5	89.1
Thr	14.2	0.0	3.1							13.9		2.1	1.6		1.6	6.3	*					42.9
Trp		9.1			1.3			0.9			1.1					0.2		*			5.2	17.8
Tyr			8.4	2.0	7.4				12.4					3.3		0.8			*		6.0	40.4
Val	27.3			7.8			10.7	4.4		7.1	4.2		6.1	2.4						*		70.0
X		0.9			0.2	0.6	0.1	0.1			0.3	0.4				0.1		0.5	0.2		*	3.2
Total	49.4	76.5	49.0	38.8	22.5	28.5	44.7	51.6	35.9	56.5	69.4	42.5	23.5	33.9	62.7	87.3	68.6	8.0	35.7	61.0	54.0	1000.0

Frequencies are adjusted so as to give the expected number of changes per 1,000 nonsynonymous mutations. Blanks correspond to amino acid replacements that require multiple mutational steps. An X designates termination codons, whereas asterisks (*) indicate synonymous changes.

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