Skip to main content
Figure 4 | BMC Molecular Biology

Figure 4

From: Down-regulation of human topoisomerase IIα expression correlates with relative amounts of specificity factors Sp1 and Sp3 bound at proximal and distal promoter regions

Figure 4

Sp3 maintains transcriptional repression in the presence of Sp1. All transfections were carried out in triplicate with 1.0 μg of -617 wt topoisomerase IIα reporter plasmid and 1 μg of pCMV Sport β-galactosidase control vector. Relative luciferase activity was calculated by arbitrarily setting the control (no added Sp1 or Sp3) to 100%. Results are expressed as ± SEM where n = 9, *** p < 0.001, ** p < 0.01, and * p < 0.05

Back to article page

BMC Molecular Biology

ISSN: 1471-2199

Contact us