Figure 6

The distribution of active histone modifications on mouse α-like and β-like globin gene clusters in asynchronized (A) and mitotic (M) MEL cells. A, B. The changes of H3 and H4 acetylation level on the distant regulatory elements of globin loci in A and M cell populations. C, D. The changes of H3-K4 and H3-K79 dimethylataion on the distant regulatory elements of globin loci in A and M cell populations. The relative level of histone modifications at HS sites of globin clusters in A and M cell populations were analyzed after normalizing the DNA amount differences in A and M cell populations through DNA input (In-A and In-M).