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Table 1 Transcripts whose levels are increased by at least 2 fold in αT3-myrAKT1 when compared with mock-αT3. Transcripts identified as KSRP targets (see Table 3) are typed in bold.

From: Identification of a set of KSRP target transcripts upregulated by PI3K-AKT signaling

  Transcript name Accession number Protein function Fold increase
1 CDP-diacylglycerol-inositol 3-phosphatidyltransferase (phosphatidylinositol synthase) NM_006319 Catalyzes the biosynthesis of phosphatidylinositol. 3.74
2 SNAP91, synaptosomal-associated protein, 91 kDa homolog NM_014841 Component of clathrin-coated vescicles. 3.71
3 Solute carrier organic anion transporter family, member 1C1 NM_017435.2 Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones thyroxine (T4) and rT3. 3.39
4 Heterogeneous nuclear ribonucleoprotein F (hnRNPF) NM_004966 RNA binding protein, splicing. 3.20
5 Fibroblast growth factor 5 NM_004464 Oncogene, can transform NIH 3T3 cells. 3.20
6 Tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 NM_025235.2 Involved in the regulation of telomere length. 3.15
7 Fibroblast growth factor 19 NM_005117 Has a role in brain development, overexpressed in colon adenocarcinoma cell line. 3.12
8 Heterogeneous nuclear ribonucleoprotein A/B (hnRNPA/B) M65028 RNA binding protein. 3.11
9 Microtubule-associated protein RP/EB family member 1 NM_012325 Component of the microtubule cytoskeleton. 3.10
10 Protocadherin beta 9 NM_019119 Calcium-dependent cell-adhesion protein. 3.00
11 H3 histone, family 3A (H3.3A) NM_002107.3 Replacement histone, replication independent protein. 2.96
12 Thyroid hormone receptor interactor 4 NM_016213 Transcriptional coactivator of nuclear receptors. 2.90
13 ELL associated factor 2 NM_018456 Transcriptional transactivator of ELL and ELL2 elongation activities. 2.87
14 RUN and SH3 domain containing 1 NM_014328 Signaling adapter. 2.86
15 Cytochrome c oxidase subunit VIIc NM_001867 Component of cytochrome c oxidase. 2.80
16 Zinc finger protein 192 NM_006298 Transcriptional regulator. 2.68
17 Notch homolog 3 NM_000435 Forms a transcriptional activator complex. 2.66
18 PHD finger protein 12 NM_001033561 Transcriptional repressor. 2.65
19 GNAS complex locus (Gsα) NM_000516 Guanine nucleotide-binding protein. 2.60
20 Nascent-polypeptide-associated complex alpha polypeptide NM_005594 Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum. 2.58
21 Protein phosphatase 1, catalytic subunit, beta isoform NM_002709 Ser/Thr phosphatase, essential for cell division. 2.55
22 Sorbin and SH3 domain containing 1 (SORBIN) NM_001034955 Involved in insulin receptor signaling. 2.51
23 Phosducin-like NM_005388 G protein modulator. 2.51
24 Immunoglobulin mu-binding protein 2 NM_002180.1 DNA binding protein. 2.50
25 ornithine decarboxylase antizyme 1 NM_004152 Destabilizes and promotes degradation of ornithine decarboxylase. 2.49
26 Septin 5 NM_002688 Involved in cytokinesis. 2.44
27 epidermal growth factor NM_001963.2 Growth factor. 2.40
28 Fibrosin 1 NM_022452 Fibrogenic lymphokine. 2.31
29 Death-associated protein kinase 1 NM_004938 Pro-apoptotic calcium/calmodulin-dependent serine/threonine kinase. 2.29
30 Caveolin 2 NM_001233 Scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. 2.28
31 Dual specificity protein phosphatase 4 NM_001394 Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2. 2.14
32 Brix domain-containing protein 2 NM_018321 Biogenesis of the 60S ribosomal subunit. 2.07
33 Catenin beta (CTNNB) * NM_007614.2 Wnt signaling, cell transformation 2.05
34 Protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform (PP2ACA) NM_002715 Dephosphorylates several Ser/Thr kinases. 2.02
35 Heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) NM_002136 RNA binding protein. 2.00
  1. *The regulation of Catenin beta by PI3K-AKT signaling has been described elsewhere [12].