Table 1 Transcripts whose levels are increased by at least 2 fold in αT3-myrAKT1 when compared with mock-αT3. Transcripts identified as KSRP targets (see Table 3) are typed in bold.

1

CDP-diacylglycerol-inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)

NM_006319

Catalyzes the biosynthesis of phosphatidylinositol.

3.74

2

SNAP91, synaptosomal-associated protein, 91 kDa homolog

NM_014841

Component of clathrin-coated vescicles.

3.71

3

Solute carrier organic anion transporter family, member 1C1

NM_017435.2

Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones thyroxine (T4) and rT3.

3.39

4

Heterogeneous nuclear ribonucleoprotein F (hnRNPF)

NM_004966

RNA binding protein, splicing.

3.20

5

Fibroblast growth factor 5

NM_004464

Oncogene, can transform NIH 3T3 cells.

3.20

6

Tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2

NM_025235.2

Involved in the regulation of telomere length.

3.15

7

Fibroblast growth factor 19

NM_005117

Has a role in brain development, overexpressed in colon adenocarcinoma cell line.

3.12

8

Heterogeneous nuclear ribonucleoprotein A/B (hnRNPA/B)

M65028

RNA binding protein.

3.11

9

Microtubule-associated protein RP/EB family member 1

NM_012325

Component of the microtubule cytoskeleton.

3.10

10

Protocadherin beta 9

NM_019119

Calcium-dependent cell-adhesion protein.

3.00

11

H3 histone, family 3A (H3.3A)

NM_002107.3

Replacement histone, replication independent protein.

2.96

12

Thyroid hormone receptor interactor 4

NM_016213

Transcriptional coactivator of nuclear receptors.

2.90

13

ELL associated factor 2

NM_018456

Transcriptional transactivator of ELL and ELL2 elongation activities.

2.87

14

RUN and SH3 domain containing 1

NM_014328

Signaling adapter.

2.86

15

Cytochrome c oxidase subunit VIIc

NM_001867

Component of cytochrome c oxidase.

2.80

16

Zinc finger protein 192

NM_006298

Transcriptional regulator.

2.68

17

Notch homolog 3

NM_000435

Forms a transcriptional activator complex.

2.66

18

PHD finger protein 12

NM_001033561

Transcriptional repressor.

2.65

19

GNAS complex locus (Gsα)

NM_000516

Guanine nucleotide-binding protein.

2.60

20

Nascent-polypeptide-associated complex alpha polypeptide

NM_005594

Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum.

2.58

21

Protein phosphatase 1, catalytic subunit, beta isoform

NM_002709

Ser/Thr phosphatase, essential for cell division.

2.55

22

Sorbin and SH3 domain containing 1 (SORBIN)

NM_001034955

Involved in insulin receptor signaling.

2.51

23

Phosducin-like

NM_005388

G protein modulator.

2.51

24

Immunoglobulin mu-binding protein 2

NM_002180.1

DNA binding protein.

2.50

25

ornithine decarboxylase antizyme 1

NM_004152

Destabilizes and promotes degradation of ornithine decarboxylase.

2.49

26

Septin 5

NM_002688

Involved in cytokinesis.

2.44

27

epidermal growth factor

NM_001963.2

Growth factor.

2.40

28

Fibrosin 1

NM_022452

Fibrogenic lymphokine.

2.31

29

Death-associated protein kinase 1

NM_004938

Pro-apoptotic calcium/calmodulin-dependent serine/threonine kinase.

2.29

30

Caveolin 2

NM_001233

Scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.

2.28

31

Dual specificity protein phosphatase 4

NM_001394

Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2.

2.14

32

Brix domain-containing protein 2

NM_018321

Biogenesis of the 60S ribosomal subunit.

2.07

33

Catenin beta (CTNNB) *

NM_007614.2

Wnt signaling, cell transformation

2.05

34

Protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform (PP2ACA)

NM_002715

Dephosphorylates several Ser/Thr kinases.

2.02

35

Heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1)

NM_002136

RNA binding protein.

2.00