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Figure 1 | BMC Molecular Biology

Figure 1

From: Studies on the CPA cysteine peptidase in the Leishmania infantum genome strain JPCM5

Figure 1

Alignment of CPA amino acid sequences. Alignment of deduced amino acid sequence of LiCPA (CAD12932) from L. infantum JPCM5, with deduced amino acid sequences obtained from GenBank. These included L. majo r (LmjCPA, CAC18865.1), L. mexicana (lmxCPA, CAA44094), L. donovani (LdCPA, AAK27384.1), L. chagasi (LdcCPA, AAC38833) and L. braziliensis (LbCPA, LbrM19.1180). The dots represent amino acid identity. The arrows show the predicted cleavage sites of pro/mature domains and mature/C-terminal extension, respectively. Amino acid residues important for the catalysis are indicated as follows : active site cysteine C153 (â—‡), the predicted catalytic dyads H289 and N309 (â—Ź) and the predicted glutamine of the oxyanion hole Q147 (â–Ľ). The potential glycosylation sites are shown in boxes.

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