Figure 1
From: Regulation of the human LAT gene by the Elf-1 transcription factor
A 450 bp region of the proximal LAT promoter. The DNA sequence extending 450 bp upstream of the translation start site for the human gene and the homologous region from the mouse genome are shown. Bases conserved between the human and mouse are shaded. The 'A' nucleotide in the translation start site ATG codon (underlined) for the human sequence has been designated as +1 in this study. The transcription start sites identified for the endogenous LAT gene in Jurkat T cells have a '●' above the site, those mapped using RNA isolated from human thymus have a '■' above the site, and those that were identified in both Jurkat cells and thymus are indicated with a '◆' above the site. Potential binding sites for transcription factors of the Ets and Runx family are indicated with a bar above the site and the transcription factor name. Specific point mutations introduced into the -1000 to -1 promoter fragment are indicated below each site.