Skip to main content
Figure 6 | BMC Molecular Biology

Figure 6

From: The transcription factor ATF3 is upregulated during chondrocyte differentiation and represses cyclin D1 and A gene transcription

Figure 6

Model for ATF3 action in chondrocyte differentiation. We suggest that induction of ATF3 by differentiation stimuli antagonizes the CRE-dependent expression of cyclin D1 and cyclin A, which are induced by mitogenic stimuli through ATF2 and CREB. Reduced cyclin-dependent kinase activity and hypophosphorylation of pocket proteins in response to ATF3 upregulation then results both in cell cycle exit and in increased activity of Runx2, promoting chondrocyte differentiation.

Back to article page

BMC Molecular Biology

ISSN: 1471-2199

Contact us