Multiple alignment of the deduced amino acid sequence of omTERT with selected vertebrate TERT homologues. TERT proteins from top to bottom are: omTERT (O. melastigma, this study), gTERT (orange-spotted grouper, Epinephelus coioides, unpublished, Genbank: DQ317442), fTERT (Fugu, Genbank: AAX59693), xTERT (Xenopus laevis, Genbank: AAG43537), cTERT (chicken, Genbank: AAS75793), hTERT (human, Genbank: NP_003210), mTERT (mouse, Genbank: NP_033380). Number on the right denotes the amino acid position. Identical amino acids shared by all protein sequences are marked with asterisks (*). Dashes (--) indicate gaps inserted for improved alignment. Residues known to be essential for telomerase activity are highlighted in bold. Conserved regions in the v-I to v-VII regions of vertebrate TERTs are labelled. Functional motifs: GQ, CP, QFP, T, 1, 2, A, B', C, D, E, E-I, E-II, E-III and E-IV are indicated by dashed lines and labelled underneath. Signature amino acid residues distinguishing TERT from other RTs are indicated by inverted triangles (▼).