Figure 5

Human ACSL transcript variants (A) and gate domains (B). A: Schematic representation of the different known transcript variants. Exons are represented by empty boxes and alternative exons by filled boxes. Translation initiator AUG and Y/F-Gate domain encoding exons are indicated. If known, a capitalized V indicates the first exon of each variant. Note that only the sequence of the Gate-domain region of ACSL1_v3 and ACSL6_v4 is known. See Results for details. B: Alignment of the Gate-domain motifs. The F and Y residues of the two Gate domains are boxed. Highly conserved residues are shaded. Note that more residues are conserved among human ACSL isoforms. Position of the first and last residues shown is indicated on the left and right, respectively. Note that only the Gate-domain region of ACSL1_v3 and ACSL6_v4 is known. For clarity, ACSL3 variant 1 and 2, and ACSL5 variant 2 and 3, which encode the same isoform, are annotated as ACSL3_v1v2 and ACSL5_v2v3, respectively.