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Table 1 Relative luciferase activity of the DRD4 promoter constructs. Luciferase activities of the crude cell extracts were normalized to their β-galactosidase activities. Data are shown as the mean ± SD. Results of a representative experiment are shown as measured in triplicates. Similar data were obtained from three independent transfection experiments.

From: No direct effect of the -521 C/T polymorphism in the human dopamine D4 receptor gene promoter on transcriptional activity

Luciferase/β-gal ratio

SK-N-F1

Y79

IMR32

HeLa

pGL3-Basic

3.52 ± 1.43

3.87 ± 0.09

3.70 ± 0.29

3.59 ± 0.13

pDRD4-A

10.35 ± 1.00

8.80 ± 1.29

6.77 ± 0.86

8.71 ± 0.78

pDRD4-B

31.63 ± 4.7

26.89 ± 4.51

10.56 ± 0.52

27.08 ± 1.54

pDRD4-C

34.09 ± 3.34

28.98 ± 4.61

9.45 ± 0.46

21.89 ± 0.99

pDRD4-D

0.42 ± 0.02

1.75 ± 0.15

1.97 ± 0.12

2.56 ± 0.14

pDRD4-E

1.66 ± 0.20

4.18 ± 0.38

1.76 ± 0.22

2.51 ± 0.31

pDRD4-F

1.75 ± 0.17

4.21 ± 0.23

1.77 ± 0.16

2.63 ± 0.30

pTK-luc

84.21 ± 10.76

114.97 ± 10.50

28.73 ± 2.29

172.35 ± 2.05