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Figure 1 | BMC Molecular Biology

Figure 1

From: DNA deformability changes of single base pair mutants within CDE binding sites in S. Cerevisiae centromere DNA correlate with measured chromosomal loss rates and CDE binding site symmetries

Figure 1

CDEI & CDEIII sequences, their associated mutant's chromosome loss rates, and approximate locations of the DNA-protein components in a centromere nucleosome model. At the top the three main conserved wild type DNA sequences, CDEI, CDEII, and CDEIII are represented. The core palindromes are marked by bold arrows and the symmetry centers by asterisks. The flanking palindrome areas of CDEIII are indicated by lighter arrows. Below each of the wild type sequences, the different mutant bases tested for each wild type base position are shown. Beneath each mutant, the bold vertical line indicates it's relative loge (loss) rate, of magnitude indicated by the log scale shown. These data are recreated from Hegemann et al [7] Figure 3. The inset depicts a model of the yeast centromere showing the modified nucleosome formed by wrapping the CDEI site into close proximity to CDEIII. Also shown are their associated protein complexes that along with additional binding proteins form the kinetochore, which bind the spindle microtubule [2].

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BMC Molecular Biology

ISSN: 1471-2199

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