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Figure 8 | BMC Molecular Biology

Figure 8

From: Zinc-finger domains of the transcriptional repressor KLF15 bind multiple sites in rhodopsin and IRBP promoters including the CRS-1 and G-rich repressor elements

Figure 8

Alignment of (A) rhodopsin and (B) IRBP proximal promoters. KLF15 protected sites in bovine promoter are boxed; 9 bp KLF15 binding sites predicted using Target Explorer Matrix with a cutoff score of 4.86 (Table 1; see also Additional file: 1) are underlined and in bold; at locations where multiple overlapping binding sites were predicted, only the one with the highest score is marked. Previously identified protein binding sites/regulatory elements are indicated by heavy solid bars above sequence. Numbering is based on the bovine promoter sequence and an arrowhead indicates the transcriptional start site (+1). B, bovine; H, Human; C, chimp; D, dog; R, rat; M, mouse.

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