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Table 5 Search of MKL-dependent and -independent serum-inducible promoters for SRF binding sites.

From: Expression profiling of serum inducible genes identifies a subset of SRF target genes that are MKL dependent

A. Exact matches to CArG box

 

genes in micro-array

genes in DBTSS

matches

frequency

p

genes with matches

frequency

p

genes w. >1 matches

frequency

p

Total genes

14824

6875

419

0.061

 

401

0.058

 

15

0.002

 

All Serum-inducible

150

95

17

0.179

0.0001

11

0.116

0.0218

3

0.032

0.0010

MKL-indep, serum-inducible

122

75

14

0.187

0.0002

9

0.120

0.0293

2

0.027

0.0101

MKL-dep, serum-inducible

28

20

3

0.150

0.1193

2

0.100

0.3245

1

0.050

0.0392

B. Matches to CArG box allowing one base mismatch

Total genes

14824

6875

6707

0.98

 

4230

0.615

 

1744

0.254

 

All Serum-inducible

150

95

103

1.08

0.155

63

0.663

0.1958

25

0.263

0.4576

MKL-indep, serum-inducible

122

75

72

0.96

0.839

47

0.627

0.4682

15

0.200

0.8886

MKL-dep, serum-inducible

28

20

31

1.55

0.005

16

0.800

0.0666

10

0.500

0.0155

  1. The promoters from indicated groups were searched for exact matches with the CArG box sequence CC(A/T)6GG (A) or allowing for one base mismatch (B). Frequency indicates the number of matches divided by the number of DBTSS genes in each category. The p values were calculated based on a binomial distribution except for the value for matches in (B) (column 6 from the left) where the numbers were too large and the Poisson distribution of the frequency of matches per base was used.