|
A. Exact matches to CArG box
|
|---|
| |
genes in micro-array
|
genes in DBTSS
|
matches
|
frequency
|
p
|
genes with matches
|
frequency
|
p
|
genes w. >1 matches
|
frequency
|
p
|
|---|
|
Total genes
|
14824
|
6875
|
419
|
0.061
| |
401
|
0.058
| |
15
|
0.002
| |
|
All Serum-inducible
|
150
|
95
|
17
|
0.179
|
0.0001
|
11
|
0.116
|
0.0218
|
3
|
0.032
|
0.0010
|
|
MKL-indep, serum-inducible
|
122
|
75
|
14
|
0.187
|
0.0002
|
9
|
0.120
|
0.0293
|
2
|
0.027
|
0.0101
|
|
MKL-dep, serum-inducible
|
28
|
20
|
3
|
0.150
|
0.1193
|
2
|
0.100
|
0.3245
|
1
|
0.050
|
0.0392
|
|
B. Matches to CArG box allowing one base mismatch
|
|
Total genes
|
14824
|
6875
|
6707
|
0.98
| |
4230
|
0.615
| |
1744
|
0.254
| |
|
All Serum-inducible
|
150
|
95
|
103
|
1.08
|
0.155
|
63
|
0.663
|
0.1958
|
25
|
0.263
|
0.4576
|
|
MKL-indep, serum-inducible
|
122
|
75
|
72
|
0.96
|
0.839
|
47
|
0.627
|
0.4682
|
15
|
0.200
|
0.8886
|
|
MKL-dep, serum-inducible
|
28
|
20
|
31
|
1.55
|
0.005
|
16
|
0.800
|
0.0666
|
10
|
0.500
|
0.0155
|
- The promoters from indicated groups were searched for exact matches with the CArG box sequence CC(A/T)6GG (A) or allowing for one base mismatch (B). Frequency indicates the number of matches divided by the number of DBTSS genes in each category. The p values were calculated based on a binomial distribution except for the value for matches in (B) (column 6 from the left) where the numbers were too large and the Poisson distribution of the frequency of matches per base was used.
