Figure 2

Hierarchical clustering of gene expression. RNA from WT and DN-MKL1 expressing cells induced with serum for the indicated times was used to probe an Affymetrix mouse chip with 14,824 non-redundant probes. dChip software was used to identify genes with significant variation across samples. 229 such genes were used for clustering analysis. Different classes of similarly regulated genes are indicated to the right and discussed in the text. The respective positions where the previously characterized MKL target genes srf, vinculin and c-fos fall are indicated by the arrows. Expression scales ranging from -3 (blue) to +3 (red) fold are indicated at the bottom of the figure.