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Table 1 Overview of all tested interactions within the Dnmt family.

From: Interactions within the mammalian DNA methyltransferase family

  cloned in pACT2 cloned in pBMT117c.1 lacZ HIS3 Comments
  Dnmt 2 N-Dnmt 1 - -  
  N-Dnmt 3a C-Dnmt 1 - -  
  C-Dnmt 3a N-Dnmt 1 - -  
Dnmt 1 N-Dnmt 3b C-Dnmt 1 - -  
  C-Dnmt 3b N-Dnmt 1 - -  
vs DNMT 3L C-Dnmt 1 - -  
  DNMT 3L N-Dnmt 1 (+/+) - weak autoactivation
  DNMT 3L control (+/+) - weak autoactivation
other Dnmt's N-Dnmt 1 DNMT 3L - -  
  N-Dnmt 1s DNMT 3L - - short isoform Dnmt1
  DNMT 3L N-Dnmt 1s (+) - weak autoactivation
  Dnmt 2 C-Dnmt 1 - -  
Dnmt 3a control C-Dnmt 3a - -  
  control C-Dnmt 3b - -  
vs C-Dnmt 3a N-Dnmt 3a - -  
  C-Dnmt 3b N-Dnmt 3b - -  
Dnmt 3b N-Dnmt 3a C-Dnmt 3a - -  
  N-Dnmt 3b C-Dnmt 3b - -  
  DNMT 3L control (+/+) - weak autoactivation
  control C-Dnmt 3a - -  
DNMT 3L control C-Dnmt 3b - -  
  DNMT 3L N-Dnmt 3a (+) - weak autoactivation
vs DNMT 3L N-Dnmt 3b (+) - weak autoactivation
  DNMT 3L C-Dnmt 3a +++/+++ ++/++  
other Dnmt's C-Dnmt 3a DNMT 3L +++ +++  
  DNMT 3L C-Dnmt 3b +/+ -  
  C-Dnmt 3b DNMT 3L +++ +++  
  Dnmt 2 DNMT 3L - -  
Dnmt 2 Dnmt 2 control - -  
  Dnmt 2 N-Dnmt 1 - -  
vs Dnmt 2 C-Dnmt 1 - -  
  Dnmt 2 N-Dnmt 3a - -  
other Dnmt's Dnmt 2 N-Dnmt 3b - -  
  Dnmt 2 DNMT 3L - -  
  MBD 2 MBD 3 ++ ++ positive control
  MBD 2 N-Dnmt 1 - -  
MBD2 MBD 2 C-Dnmt 1 - -  
  MBD 2 N-Dnmt 3a - -  
vs MBD 2 N-Dnmt 3b - -  
  MBD 2 DNMT 3L - -  
Dnmt's Dnmt 2 MBD 2 ++ +++ strong autoactivation
  Dnmt 2 MBD 2 ++ +++ strong autoactivation
  control MBD 2 ++ +++ strong autoactivation
MBD3 MBD 3 N-Dnmt 1 - -  
  MBD 3 C-Dnmt 1 - -  
vs MBD 3 N-Dnmt 3a - -  
  MBD 3 N-Dnmt 3b - -  
Dnmt's MBD 3 DNMT 3L - -  
  1. The results are grouped in six panels corresponding to the different proteins tested. To allow for completeness within each panel, some of the results are presented in two different panels. N-Dnmt1s corresponds to the N-terminal domain of the short isoform, while the other abbreviations are explained in the text. Duplicate results are separated by a (/).