Interactions within the Dnmt family. Several combinations of N- and C-terminal domains of Dnmt1, Dnmt3a and Dnmt3b as well as whole Dnmt2 and DNMT3L were tested for interaction. The results are compiled in Table 1 and a subset is diagrammed here. A. N-terminus of Dnmt1, Dnmt3a and Dnmt3b versus their corresponding C-terminus; B. (top) N-Dnmt1 versus Dnmt2, DNMT3L, C-Dnmt3a and C-Dnmt3b; B. (bottom) C-Dnmt1 versus Dnmt2, DNMT3L, N-Dnmt3a and N-Dnmt3b; C. DNMT3L versus the N-Dnmt1, Dnmt2, N- and C-Dnmt3a, N- and C-Dnmt3b. The interactions were scored as in Fig. 1 and each member of a pair showing interaction was tested singly to rule out autoactivation. DNMT3L cloned in pACT2 shows weak autoactivation (marked a; see also Table 1).