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Table 5 Liver damage caused by adenoviruses. The liver lesions were assessed, as described in table 4, two and seven days after the intravenous injection of the adenoviral vector. The total liver inflammation and damage scores range from 0–6 and 0–24 respectively. The transaminase (ALAT) was measured in the serum on day 2 and 7. The normal value of ALAT, measured in ten healthy animals, is 59 +/-19 IU/l. 6 animals per group. The values indicate the mean ± sd

From: Genetic heterogeneity in response to adenovirus gene therapy

  High dose (1010 iu) Low dose (109 iu)
  Brown Norway Wag / Rij Brown Norway Wag / Rij
Total liver inflammation     
   • Day 2 0.50 ± 0.31 0.41 ± 0.37 0.58 ± 0.20 0.41 ± 0.20
   • Day 7 3 ± 1.0 1.3 ± 0.4 1.08 ± 0.49 0.66 ± 0.25
Total liver damage     
   • Day 2 2.6 ± 0.5 2.1 ± 0.7 0.8 ± 0.4 0.5 ± 0.2
   • Day 7 14.5 ± 2.6 9.3 ± 1.1 4.9 ± 0.8 2.7 ± 0.7
ALAT (IU/l)     
   • Day 2 63 ± 15 58 ± 16 44 ± 22 55 ± 19
   • Day 7 218 ± 33 104 ± 17 86 ± 27 86 ± 27
γGT (IU /l) day 2 4.5 ± 0.6 4.8 ± 0.5 Not done Not done
LDH (IU /l) day 2 837 ± 249 741 ± 356 Not done Not done
INF-γ (pg / ml) day 2 60 ± 14 65 ± 18 Not done Not done
Liver proteins (mg/g tissue)     
   • Day 2 150 ± 21 150 ± 33 110 ± 21 120 ± 18
   • Day 7 167 ± 32 177 ± 31 130 ± 42 136 ± 25
Luciferase (104 RLU/mg protein)     
   • Day 2 441 ± 158 31 ± 27 1.2 ± 0.3 0.25 ± 0.12
   • Day 7 451 ± 128 44 ± 29 1.5 ± 0.5 0.27 ± 0.17