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Table 2 Percentage of hepatocytes expressing β-Galactosidase after iv injection of Ad5 Adapt LacZ. The blue nuclei were counted on a 200 × magnification field of a liver section. Four fields per section, 4 sections per animal. Data are expressed as mean ± SD

From: Genetic heterogeneity in response to adenovirus gene therapy

   Percentage of blue hepatocytes
   Wag/Rij Brown Norway
Dose N Portal area Centro-lobular area Portal area Centro-lobular area
10 10 iu 3 82 ± 5.1 69 ± 4.6 92 ± 4.5 74 ± 3.0
3.10 9 iu 3 37 ± 11.3 32 ± 11.3 57 ± 20.5 49 ± 15.6
10 9 iu 6 10 ± 0.7 8 ± 0.7 19 ± 4.6 14 ± 2.5