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Table 2 Percentage of hepatocytes expressing β-Galactosidase after iv injection of Ad5 Adapt LacZ. The blue nuclei were counted on a 200 × magnification field of a liver section. Four fields per section, 4 sections per animal. Data are expressed as mean ± SD

From: Genetic heterogeneity in response to adenovirus gene therapy

  

Percentage of blue hepatocytes

  

Wag/Rij

Brown Norway

Dose

N

Portal area

Centro-lobular area

Portal area

Centro-lobular area

10 10 iu

3

82 ± 5.1

69 ± 4.6

92 ± 4.5

74 ± 3.0

3.10 9 iu

3

37 ± 11.3

32 ± 11.3

57 ± 20.5

49 ± 15.6

10 9 iu

6

10 ± 0.7

8 ± 0.7

19 ± 4.6

14 ± 2.5