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Table 6 Intracellular concentration (μM) of ApppN as a function of stress treatments, HNT2 genotype, and moderate overexpression of lysyl aminoacyl-tRNA synthetase

From: Control of dinucleoside polyphosphates by the FHIT-homologous HNT2 gene, adenine biosynthesis and heat shock in Saccharomyces cerevisiae

Relevant Genotype

-his

1 M sorbitol

10 mM caffeine

2 mM CdCl2

46°C

H2O

YPD

HNT2

0.58 ± 0.36

1.19 ± 0.37

1.15 ± 0.12

1.12 ± 0.29

2.16 ± 0.10

0.54 ± 0.12

0.44 ± 0.09

HNT2 YEpKRS1

0.60 ± 0.51

0.84 ± 0.21

2.74 ± 1.37

1.14 ± 0.17

2.11 ± 0.25

0.49 ± 0.05

0.41 ± 0.13

hnt2Δ

10.7 ± 7.51

6.65 ± 0.82

12.5 ± 3.91

4.92 ± 2.67

44.2 ± 7.51

5.92 ± 1.66

5.97 ± 1.38

hnt2Δ YEpKRS1

19.0 ± 8.21

6.36 ± 2.10

3.84 ± 1.05

11.6 ± 4.36

40.6 ± 5.62

8.82 ± 3.57

1.40 ± 0.52