Liver damage in relation with the dose of adenoviral vectors. On the left Y axis is plotted the luciferase activity measured in the liver of Brown Norway rats 2 days after iv injection of graded doses of Ad Adapt Luc (squares). On the right Y axis is plotted the liver damage score observed 7 days after iv injection of graded doses of Ad Adapt Empty (circles). The vp / iu ratio of both vectors were similar. Therefore, for a given luciferase activity in the liver, one can read on the graph the corresponding liver damage (the bleu and red lines). The values A (bleu) and B (red) are the luciferase activity in the liver after the intratumoral injection of 1010iu and 5.109iu Ad adapt Luc respectively (see figure 8). The value A and B correspond to intravenous doses of 3.5 109iu and 1.2 109iu respectively. These doses induce a liver damage score between 2 and 4 (circle line).