Figure 1

A comparison of ammo acid sequences of the Itt1 protein of S. cerevisiae and its best homologues from Schizosaccharomyces pombe (GenBank CAB65614.1), man (androgen receptor activator ARA54, NP_004281.1) and C. elegans (AAB52683.1). Sequences were aligned by introducing gaps (...). Conservative amino acids are highlighted in black (cysteines and histidines) and gray and shown as "consensus". The putative nuclear import signal is underlined. The similarities between the second and third double zinc finger elements are shown by lines. In the third element, the residues presumably involved in zinc binding are numbered. In the earlier assignment [17], these are 1,2, &,$ , 3, 4, 5, 6, with $ corresponding to histidine of some other TRIAD sequences.