Pten heterozygosity accelerates tumor appearance in Wnt-1 TG females (A) and males (B). Percentages of mice that were tumor-free, as determined by weekly visual inspection and/or palpation, were plotted against the age when tumors were found. Genotypes and sizes are as indicated. For the Pten+/- female group without the Wnt-1 transgene, 10 mice were monitored to 30 weeks of age; among the 10 mice, 5 were kept for another 15 weeks of age. (A) All mice showed at least one adenocarcinoma. (B) The Wnt-1 TG, Pten+/+ cohort (13) had 1 mammary and 3 salivary tumors, and the Wnt-1 TG, Pten+/- cohort (22) had 2 mammary, 6 muzzle, and 14 salivary tumors.