Figure 7

Model for the known GATA pathways in mature small intestine, and the placement of SPDEF within those pathways. GATA4 (purple), but not GATA6 (blue), activates and represses a subset of absorptive enterocyte genes (GATA4-specific), whereas either GATA4 or GATA6 (purple/blue) promote crypt cell proliferation, enteroendocrine lineage commitment, Paneth cell differentiation, and absorptive enterocyte gene expression (GATA4/GATA6-redundant). GATA4/GATA6 promotes the crypt cell proliferation function by repressing the gene encoding SPDEF (green).