Biological disease networks mediated by KLF11 and its mutants. Using Ingenuity’s network analysis tool, significantly regulated genes by KLF11 (A) and its A347S (B) and Δ486 (C) mutants were examined for connectivity. Networks were scored by relevance and a p-value assigned by Fisher’s Exact Test to discriminate networks generated by chance alone. A threshold of p < 0.05 was employed to determine significant networks. Networks were then assessed for association to known biological or disease processes. Wild type KLF11 and its mutants share three processes: death and survival, hereditary disorders, and molecular transport. Of the identified processes, 10 are unique to wild type KLF11 and 6 and 8 are unique to the A347S and Δ486 mutants, respectively. A number of known KLF11-mediated biological and diseases processes were revealed by this analysis, providing an internal control, including endocrine disorders, gastrointestinal disorders, and cellular growth and proliferation processes. However, the analysis also generated a number of novel biological and disease processes that remain to be experimentally validated for KLF11.