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Table 2 Top ten biological processes and pathways associated to up-regulated miRNAs in TIA-depleted HeLa cells

From: Identification of a set of miRNAs differentially expressed in transiently TIA-depleted HeLa cells by genome-wide profiling

Term

Description

Number of genes

p-value

GO

 

GO:0006355

Regulation of transcription, DNA-dependent

269

2.49E-33

GO:0007165

Signal transduction

188

1.00E-18

GO:0007275

Multicellular organismal development

151

5.17E14

GO:0045944

Positive regulation of transcription from RNA pol II promoter

124

2.69E-21

GO:0007155

Cell adhesion

103

4.06E-12

GO:0055085

Transmembrane transport

102

5.89E-08

GO:0045893

Positive regulation of transcription, DNA-dependent

96

5.89E-14

GO:0006915

Apoptotic process

96

4.13E-07

GO:0000122

Negative regulation of transcription from RNA pol II promoter

95

4.66E-17

GO:0007399

Nervous system development

93

1.98E-16

KEGG

 

Kegg:05200

Pathways in cancer

68

5.72E-11

Kegg:04010

MAPK signaling pathway

58

3.68E-08

Kegg:04510

Focal adhesion

49

2.75E-08

Kegg:04144

Endocytosis

46

7.60E-07

Kegg:04810

Regulation of actin cytoskeleton

44

1.48E-04

Kegg:04310

Wnt signaling pathway

37

3.88E-05

Kegg:04080

Neuroactive ligand-receptor interaction

35

9.43E-04

Kegg:04724

Glutamatergic synapse

32

2.34E04

Kegg:04120

Ubiquitin mediated proteolysis

31

5.96E-03

Kegg:05152

Tuberculosis

28

1.17E-04

  1. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) databases analysis were carried out using GeneCodis3 software. The categories were ranked on their numbers of associated genes and the ten with the highest number of genes are shown.