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Table 2 Top ten biological processes and pathways associated to up-regulated miRNAs in TIA-depleted HeLa cells

From: Identification of a set of miRNAs differentially expressed in transiently TIA-depleted HeLa cells by genome-wide profiling

Term Description Number of genes p-value
GO:0006355 Regulation of transcription, DNA-dependent 269 2.49E-33
GO:0007165 Signal transduction 188 1.00E-18
GO:0007275 Multicellular organismal development 151 5.17E14
GO:0045944 Positive regulation of transcription from RNA pol II promoter 124 2.69E-21
GO:0007155 Cell adhesion 103 4.06E-12
GO:0055085 Transmembrane transport 102 5.89E-08
GO:0045893 Positive regulation of transcription, DNA-dependent 96 5.89E-14
GO:0006915 Apoptotic process 96 4.13E-07
GO:0000122 Negative regulation of transcription from RNA pol II promoter 95 4.66E-17
GO:0007399 Nervous system development 93 1.98E-16
Kegg:05200 Pathways in cancer 68 5.72E-11
Kegg:04010 MAPK signaling pathway 58 3.68E-08
Kegg:04510 Focal adhesion 49 2.75E-08
Kegg:04144 Endocytosis 46 7.60E-07
Kegg:04810 Regulation of actin cytoskeleton 44 1.48E-04
Kegg:04310 Wnt signaling pathway 37 3.88E-05
Kegg:04080 Neuroactive ligand-receptor interaction 35 9.43E-04
Kegg:04724 Glutamatergic synapse 32 2.34E04
Kegg:04120 Ubiquitin mediated proteolysis 31 5.96E-03
Kegg:05152 Tuberculosis 28 1.17E-04
  1. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) databases analysis were carried out using GeneCodis3 software. The categories were ranked on their numbers of associated genes and the ten with the highest number of genes are shown.