Figure 4

RNA map of TIA proteins in targeted pre-mRNAs related with miRNAs in TIA-deficient HeLa cells. (A and B) Profiles of experimental crosslink sites of TIA1 and TIAR proteins (adapted from TIA-iCLIP analysis [8]) on up- (A) and down-regulated (B) pre-mRNAs in TIA-depleted HeLa cells. Representative examples of up- (A) and down-regulated (B) genes with low (+), medium (++) and high (+++) density of TIA binding sites are shown. The bar graph in each panel indicates the number of cDNAs that identified each crosslink site.