Figure 4
From: An evaluation of oligonucleotide-based therapeutic strategies for polyQ diseases
A comparison of RNA duplexes targeting the CAG repeat tract in HTT. A schematic representation of the duplex sequences (left panel) and the interaction of the CUG strand with CAG tracts in the HTT transcript (middle panel). The right panel shows our accumulated results (published elsewhere) of duplex activity toward HTT expression at the mRNA and protein levels in the same experimental setup: 50 nM concentration of duplexes 72 h after the transfection of the HD cell line (GM04281).