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Figure 1 | BMC Molecular Biology

Figure 1

From: Alternative splicing of the neurofibromatosis type 1 pre-mRNA is regulated by the muscleblind-like proteins and the CUG-BP and ELAV-like factors

Figure 1

Endogenous NF1 exon 23a inclusion patterns and UG-rich upstream intronic sequence. (A) A representation of endogenous NF1 exon 23a inclusion patterns. Exon 23a is predominantly included in most tissues, while it is predominantly skipped in neurons. Arrows represent RT-PCR oligonucleotides designed to analyze NF1 exon 23a splicing patterns. (B) The intronic region upstream of NF1 exon 23a is UG-rich and harbors two potential Muscleblind-like (MBNL) protein binding motifs (UGCUGU) which are underlined.

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