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Figure 8 | BMC Molecular Biology

Figure 8

From: Escherichia coli RecG functionally suppresses human Bloom syndrome phenotypes

Figure 8

Domain-based alignment of E. coli RecG and human BLM proteins. All conserved domain analysis below is from[44], RecG accession GI:42669, BLM accession GI:4557365. RecG Conserved Domains: RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. DEXDc: DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. HELICc: Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases. PRK10917: ATP-dependent DNA helicase RecG; Provisional BLM Conserved Domains: BDHCT: This is a C-terminal domain in Bloom’s syndrome DEAD helicase subfamily. DEXDc: DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. HELICc: Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases. RQC domain: This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure. The RQC domain, found only in RecQ family enzymes, is a high affinity G4 DNA binding domain. HRDC domain: The HRDC (Helicase and RNase D C-terminal) domain has a putative role in nucleic acid binding. recQ_fam: ATP-dependent DNA helicase, RecQ family. All proteins in this family for which functions are known are 3-5 DNA-DNA helicases. These proteins are used for recombination, recombinational repair, and possibly maintenance of chromosome stability. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).

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