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Figure 2 | BMC Molecular Biology

Figure 2

From: A novel 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) splice variant with an alternative exon 1 potentially encoding an extended N-terminus

Figure 2

Expression of HMGCR-1a , -1b and -1c in various human tissues. HMGCR-1a, -1b and -1c mRNA levels were determined by RT-qPCR in various human tissues using exon 1-specific primers. (A) HMGCR-1a, (B) HMGCR-1b (C) HMGCR-1c mRNA levels were normalised to a tissue-dependent factor based on five reference genes and calculated as ratios relative to the highest mRNA level (reference), which was set to 1. (D) Ratios of HMGCR-1a and HMGCR-1b mRNA levels are given on a logarithmic scale (base 2). HMGCR-1b is in low abundance compared with the canonical HMGCR-1a in most of the analysed tissues (ratio >0), except in the skin, esophagus, uterine cervix and colon (ratio <0).

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