Figure 4
From: Dual regulation of P-glycoprotein expression by Trichostatin A in cancer cell lines
Differential effect of TSA on ABCB1 alternative promoters. Group A cell lines (Hs-766 T, IMIM-PC-1, IMIM-PC-2, RWP1, PANC-1, MCF-7, K-562, HT-29, HT-29/M6, SW620 and BxPC-3) expressing the short 5′UTR MDR1 mRNA and group B cell lines (HTC-15, K5-62/Adr and MCF-7/Adr) expressing the long 5′UTR MDR1 mRNAs were treated for 24 hours with 1 μM TSA. As internal control GAPDH mRNA was also determined. Results are shown as the mean ± SD of at least three independent experiments with three replicates in each experiment.