Homology-based modeling. (A) Schematic alignment of Pae ψ and Eco ψ based on HHpred results with depicted structure-homology domain (Eco ψ, pdb code: 1em8, chain B ). The corresponding HHpred alignment of the core domains is shown below and indicates a high structural homology between the C-terminal part of Pae ψ and Eco ψ. Possible loop-extensions occurring in Pae ψ are numbered in roman numerals. ( B ) Superposition of the modeled core structure of Pae ψ (orange) obtained from MODELLER on Eco ψ in blue (pdb code: 1em8, chain B). The insertions in the Pae ψ sequence do not interfere with secondary structure elements of Eco ψ and can be assigned to loop regions. The extended loops are colored in pink and are labeled as in (A).