Figure 2
From: Recombination phenotypes of the NCI-60 collection of human cancer cells
Screening the NCI-60 for gene cluster instability (GCI). The presence of a large number of clusters or variable intensity of clusters suggests instability. Open star: gel resolution limit (1 Mb). Large red rounded rectangles: lines exhibiting gene cluster instability selected for further analysis. Small rounded rectangles: matching bands consistent with multiple lines derived from the identical patients. Known paired lines: NCI/ADR-RES & OVCAR-8 (orange), MDA-MB-435 & M14 (blue), SNB-19 & U251 (mauve). Purple arrows: lines sensitive to hmdUrd. Green italicized names: lines exhibiting microsatellite instability and defects in DNA mismatch repair.