Table 1 Summary of GO term classes enriched in SSH libraries of cadmium and phenanthrene responsive genes

Cellular Compartment

vacuolar membrane

GO:0005774

GO:0044437

mitochondrial inner membrane

GO:0005743

GO:0019866

mitochondrial respiratory chain

GO:0005746

GO:0070469

cis-Golgi network

GO:0005801

proteasome core complex

GO:0005839

integral to membrane of membrane fraction

GO:0000299

apical plasma membrane

GO:0016324

GO:0045177

protein-DNA complex

GO:0032993

cell-cell junction

GO:0005911

lipid particle

GO:0005811

microsome

GO:0005792

vesicular fraction

GO:0042598

Biological Process

antibiotic metabolism and biosynthesis

GO:0016999

GO:0017000

drug metabolic process

GO:0017144

metabolic processess (phenol, amino acids)

GO:0006584

GO:0018958

GO:0006576

GO:0006575

response to alkaloid

GO:0043279

(di) terpenoid metabolic process

GO:0006721

GO:0016101

bone development, ossification

GO:0060348

GO:0001503

vitamin A metabolic process

GO:0006776

GO:0001523

drug transport

GO:0015893

tissue remodeling

GO:0048771

mitochondrion distribution, inheritance, organization

GO:0048311

GO:0000001

GO:0048308

GO:0007005

autophagy

GO:0006914

glyoxylate cycle

GO:0006097

GO:0046487

metabolism of alditol, polyol, glycerol, aldehyde, process

GO:0019751

GO:0006071

GO:0019400

GO:0006081

fat-soluble vitamin metabolic process

GO:0006775

cellular aerobic respiration

GO:0009060

GO:0045333

peripheral nervous system development

GO:0007422

GO:0007411

(canalicular) bile acid and bile salt transport

GO:0015721

GO:0015722

histidine meta- and catabolism

GO:0006548

GO:0009075

GO:0006547

GO:0009077

monocarboxylic acid transport

GO:0015718

response to purine, caffeine

GO:0014074

GO:0031000

iron ion transport

GO:0006826

olfactory chemosensory behavior

GO:0042048

GO:0007635

acute inflammatory response

GO:0002526

tRNA aminoacylation for protein translation

GO:0006418

GO:0043039

cellular amino acid catabolic process, activation

GO:0009063

GO:0043038

GO:0044270

GO:0009310

autophagic cell death

GO:0048102

Molecular Function

N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase activity

GO:0050564

amino-acid racemase activity

GO:0047661

transition metal ion transmembrane transporter activity

GO:0046915

ATPase activity

GO:0043492

GO:0042626

GO:0015662

GO:0008553

L-ascorbic acid binding

GO:0031418

phosphopantetheine binding

GO:0031177

racemase and epimerase activity

GO:0016854

GO:0016855

hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances

GO:0016820

oxidoreductase activity

GO:0016715

P-P-bond-hydrolysis-driven transmembrane transporter activity

GO:0015405

primary active transmembrane transporter activity

GO:0015399

GO:0015082

GO:0008514

copper ion binding

GO:0005507

histone acetyltransferase activity

GO:0004402

acyl carrier activity

GO:0000036

binding: amine, chloride ion

GO:0043176

GO:0043168

GO:0031404

ATPase activity

GO:0042625

ligand-gated (ion) channel activity

GO:0022834

GO:0015276

extracellular ligand-gated ion channel activity

GO:0005230

retinol dehydrogenase activity

GO:0004745

phosphoric diester hydrolase activity

GO:0008081

threonine-type endopeptidase activity

GO:0004298

GO:0070003

cation transmembrane transporter activity

GO:0008324

GO:0015075

binding: tetrapyrrole heme, vitamin, oxygen

GO:0020037

GO:0019842

GO:0019825

GO:0046906

oxidoreductase activity

GO:0016712

GO:0016705

iron ion binding

GO:0005506

monooxygenase activity

GO:0004497

GO:0004500

oxidoreductase activity

GO:0016709

endopeptidase (-inhibitor) activity

GO:0004866

GO:0004857

GO:0004177

GO:0004867

GO:0030414

nucleoside binding

GO:0001882

aminoacyl-tRNA ligase activity

GO:0004812

Terms with the highest log₂ odds ratios (>2; GOEAST analysis), or large difference in occurrence ratio between the two SSH libraries (> 2; CateGOrizer analysis) are included in the table. * Trend of expression; higher (+), lower (-) or equal (o), based on term countings (Hu et al 2008) in the cadmium, phenanthrene and normalized library.