Table 4 Top 10 downregulated genes upon miR-128
GENE | FC | FUNCTION | ||
|---|---|---|---|---|
TMSB10 | -1.583 | Organization of the cytoskeleton, cell motility and spreading: binds to actin monomers and inhibits actin polymerization; anti-apoptotic action in chickembryo motoneurons | ||
TRAPPC4 | -1.589 | Vesicular transport from endoplasmic reticulum to golgi; possible role in postsynaptic membrane trafficking | ||
G6PC3 | -1.595 | Regulation of glucose homeostasis: catalyzes hydrolysis of G6P to glucose and phosphate | ||
VPB1 | -1.617 | Chaperone protein; maturation of the cytoskeleton and morphogenesis; possible role in the transport and correct localization of the tumor suppressor von Hippel-Lindau (VHL) protein | ||
NGFRAP1 | -1.637 | p75NTR-associated protein; mediates apoptosis in response to NGF | ||
PKIA | -1.699 | PKA inhibition | ||
YWHAB | -1.713 | Member of the brain-abundant 14-3-3 protein family; may play a role in linking mitogenic signaling and the cell cycle machinery | ||
PAIP2 | -2.034 | Translational repressor; acts on VEGF (Vascular Endothelial Growth Factor) | ||
CHGB | -2.050 | Secretory protein expressed in neuronal cells; guides and sorts the secretion of neuropeptides | ||
TROVE2 | -2.069 | RNA-binding protein; major autoantigen in patients suffering from autoimmune diseases; binds small RNAs of unknown function (Y RNAs) and misfolded noncoding RNAs; possible function in the degradation of defective RNAs |