Skip to main content

Table 3 Top 10 upregulated genes upon miR-128 overexpression in SH-SY5Y cells

From: Overexpression of miR-128 specifically inhibits the truncated isoform of NTRK3 and upregulates BCL2 in SH-SY5Y neuroblastoma cells

GENE

FC

 

FUNCTION

DYNC1I1

 

1.781

 

Microtubule-based vesicular trafficking;retrograde

axonal transport of signaling endosomes containing

neurotrophins and associated downstream kinases

HMGCS1

 

1.728

 

Lipogenesis and biosynthesis of cholesterol

BCL2

 

1.689

 

Regulation of cell death and

caspase activity; antiapoptotic

CREB3L2

 

1.652

 

Transcription factor of the CREB3 family;

astrocyte proliferation in response

to inflammation and trauma (gliosis)

TRAF3IP2

 

1.558

 

Activation of the transcription factor NFkB;

implicated in malignant processes and in the

regulation of the apoptotic response; mediates the

antiapoptotic effect of TGF-beta and TNF-alpha

ISLR2

 

1.544

 

Integral membrane protein

KLF6

 

1.544

 

Zinc finger transcription factor; adipogenesis

and inhibition of cellular growth

PRICKLE1

 

1.508

 

May regulate neurite formation

during brain development

ADIPOR1

 

1.504

 

Component of the energy homeostatic mechanism;

increases fatty acid oxidation and glucose uptake;

may participate in the control higher brain functions

PRSS3

 

1.498

 

Encodes mesotrypsin, a brain-specific

trypsin form thought to protect neural

cells from apoptotic cell death