Figure 3
From: Cell- and region-specific miR30-based gene knock-down with temporal control in the rat brain
Analyses of the efficacy of miR30-shRNA/Luc in vivo in adult rat brain. a: (1) LV-mCMV/SYN-tTA and (2) LV-mCMV/GfaABC1D-tTA mediated Dox-controllable Luc knock-down in DVC in rats. b: (1) LV-mCMV/SYN-tTA and (2) LV-mCMV/GfaABC1D-tTA mediated Dox-controllable Luc knock-down in HIP in rats. Rats in groups A, A', B and B' were not treated with Dox. Rats in groups C and C' drank Dox-containing water post-injection for 7 days. There were 3 rats in each group. A: LVVs-miRLuc-control1; B, C: LVVs-miRLuc-neurone; A': LVVs-miRLuc-control2; B', C': LVVs-miRLuc-glia. *P < 0.01, **P = 0.18, compared with group A. ♦P < 0.01, ♦♦P = 0.48, compared with group A'. •P = 0.12, ••P = 0.23, compared with group A. ♠P = 0.03, ♠♠P = 0.17, compared with group A'.