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Figure 5 | BMC Molecular Biology

Figure 5

From: Sex-biased transcription enhancement by a 5' tethered Gal4-MOF histone acetyltransferase fusion protein in Drosophila

Figure 5

HAT activity is required for robust transcription activation by Gal4-MOF. Larvae carry the UAS-RedStinger4 reporter and a hsp83-Gal4-MOF mutant transgene. (A) hsp83-Gal4-MOF[G691E] line S53 and hsp83-Gal4[DB] line S74, (B) hsp-Gal4-MOF[E714Q] line S67, (C) hsp83-Gal4-MOF[C680A] line S72, (D) Comparison of larvae that express Gal4-MOF (line S49) with larvae that express a Gal4-MOF mutant (lines S53, S67, S72) or Gal4(DB) control (line S74). Reporter gene expression is higher in female (F) than male larvae (M). Strong expression is observed in oenocytes (asterisk, panel A) in female larvae that express a Gal4-MOF HAT mutant. All larvae express the DsRed.T4 reporter in salivary glands, including Gal4[DB] control (e.g. arrow, panel A), but this is not seen in some of the larvae shown because of orientation and focal plane.

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