TY - JOUR AU - Wang, Haijuan AU - Gambosova, Katarina AU - Cooper, Zachary A. AU - Holloway, Michael P. AU - Kassai, Andrea AU - Izquierdo, Denisse AU - Cleveland, Kelly AU - Boney, Charlotte M. AU - Altura, Rachel A. PY - 2010 DA - 2010/08/31 TI - EGF regulates survivin stability through the Raf-1/ERK pathway in insulin-secreting pancreatic β-cells JO - BMC Molecular Biology SP - 66 VL - 11 IS - 1 AB - Postnatal expansion of the pancreatic β-cell mass is required to maintain glucose homeostasis immediately after birth. This β-cell expansion is regulated by multiple growth factors, including glucose, insulin, insulin-like growth factor (IGF-1) and epidermal growth factor (EGF). These mitogens signal through several downstream pathways (AKT, ERK, STAT3, and JNK) to regulate the survival and proliferation of β-cells. Survivin, an oncofetal protein with both pro-proliferative and anti-apoptotic properties, is a known transcriptional target of both IGF-1 and EGF in cancer cells. Here, we analyzed the effects of the β-cell mitogens IGF-1 and EGF on survivin regulation in the established pancreatic β-cell model cell lines, MIN6 and INS-1 and in primary mouse islets. SN - 1471-2199 UR - https://doi.org/10.1186/1471-2199-11-66 DO - 10.1186/1471-2199-11-66 ID - Wang2010 ER -