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Table 1 Survival of mice tranfected with EAT and treated with butyrate, cisplatin and both.

From: Sodium butyrate enhances the cytotoxic effect of cisplatin by abrogating the cisplatin imposed cell cycle arrest

Treatment

Life-span (days)*

T/C**

P#

Controls

10.8 ± 2.0

1

 

Butyrate

14.0 ± 4.5

1.3

0.19

Cisplatin

12.0 ± 3.5

1.1

0.53

Cisplatin + Butyrate

19.0 ± 3.4

1.8

0.0019

  1. * Albino mice were injected intraperitoneally with undiluted EAT liquid (day 0). After 24 hours (day 1) groups of five animals received another intraperitoneal injection with cisplatin, butyrate or both. Mean life spans and the standard deviations are shown.
  2. ** The ratio between the mean life spans of the treated animals (T) and the controls (C).
  3. # The probability between control and experimental groups assuming null hypothesis.
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BMC Molecular Biology

ISSN: 1471-2199

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