Table 2 Non-conservative substitutions observed in the RPS4Y proteins.

Thr → Val: polar in X, hydrophobic in Y1 and Y2

Asp → Asn: negative in X and Y1, polar in Y2

Arg → Cys: positive in X and Y1, polar/hydrophobic in Y2

Phe → Thr: hydrophobic in X, polar in Y1 and Y2

Thr → Val: polar in X and Y2, hydrophobic in Y1

Glu → Gly: negative in X, glycines in Y1 and Y2

Thr → Ile: polar in X and Y2, hydrophobic in Y1

Asp → Asn/Ser: negative in X, polar in Y1 and Y2

Thr → Ile: polar in X, hydrophobic in Y1 and Y2

Lys → Asn: positive in X, polar in Y1 and Y2

Ala → Thr: hydrophobic in X and Y2, polar in Y1