Figure 7
Schematic model of the modulation of Gli1 protein levels by genetic variation. The expression ratio of the Gli1 5' UTR variants is dependent on polymorphisms that affect the inclusion/skipping of exon 1B. The presence or not of the canonical intronic dinucleotide GT at the 5' splice site of intron 1B has a major impact in controlling exon 1B splicing. Additionally, the skipped variants have a higher translational efficiency, highlighting the importance of strain differences as modulators of HH signaling-dependent/independent Gli1 protein levels.