Figure 6
TACC1 contributes to all-trans RA activation of RAR target genes. Induction by ATRA of three RAR target genes [RARβ4 (A); Hoxa1 (B); Laminin B1 (C)] in non-targeting siRNA (open histogram) and TACC1 siRNA (black histogram) treated COS7 cells is measured by quantitative RT-PCR. Cells were treated with siRNA for 48 h before being treated with ATRA (10-7 M) for 48 h and the RNAs were extracted at different time points. The constitutive gene 36b4 was used as a control. The error bars represent the SEM (* p = 0.08, ** p < 0.05, *** p < 0.01, by Student's-test).