TY - JOUR AU - Albino, A. P. AU - Huang, X. AU - Jorgensen, E. D. AU - Gietl, D. AU - Traganos, F. AU - Darzynkiewicz, Z. PY - 2006 DA - 2006// TI - Induction of DNA double-strand breaks in A549 and normal human pulmonary epithelial cells by cigarette smoke is mediated by free radicals JO - Int J Oncol VL - 28 ID - Albino2006 ER - TY - JOUR AU - Noel, F. L. AU - Geraldine, W. L. T. PY - 2005 DA - 2005// TI - DNA repair: the importance of phosphorylating histone H2AX JO - Curr Biol VL - 15 UR - https://doi.org/10.1016/j.sbi.2005.01.009 DO - 10.1016/j.sbi.2005.01.009 ID - Noel2005 ER - TY - JOUR AU - Rogakou, E. P. AU - Pilch, D. R. AU - Orr, A. H. AU - Ivanova, U. S. AU - Bonner, W. M. PY - 1998 DA - 1998// TI - DNA double-stranded breaks induce histone H2AX phophorylation on serine 139 JO - J Biol Chem VL - 273 UR - https://doi.org/10.1074/jbc.273.10.5858 DO - 10.1074/jbc.273.10.5858 ID - Rogakou1998 ER - TY - JOUR AU - Celeste, A. AU - Petersen, S. AU - Romanienko, P. J. AU - Femandez-Capetillo, O. AU - Chen, H. T. AU - Sedelnikova, O. A. PY - 2002 DA - 2002// TI - Genomic instability in mice lacking histone H2AX JO - Science VL - 296 UR - https://doi.org/10.1126/science.1069398 DO - 10.1126/science.1069398 ID - Celeste2002 ER - TY - JOUR AU - Paull, T. T. AU - Rogakou, E. P. AU - Yamazaki, V. AU - Kirchgessner, C. U. AU - Gellert, M. AU - Bonner, W. M. PY - 2000 DA - 2000// TI - A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage JO - Curr Biol VL - 10 UR - https://doi.org/10.1016/S0960-9822(00)00610-2 DO - 10.1016/S0960-9822(00)00610-2 ID - Paull2000 ER - TY - JOUR AU - Redon, C. AU - Pilch, D. AU - Rogakou, E. AU - Sedelnikova, O. AU - Newrock, K. AU - Bonner, W. PY - 2002 DA - 2002// TI - Histone H2A variants H2AX and H2AZ JO - Curr Opin Genet Dev VL - 12 UR - https://doi.org/10.1016/S0959-437X(02)00282-4 DO - 10.1016/S0959-437X(02)00282-4 ID - Redon2002 ER - TY - JOUR AU - Burma, S. AU - Chen, B. P. AU - Murphy, M. AU - Kurimasa, A. AU - Chen, D. J. PY - 2001 DA - 2001// TI - ATM phosphorylates histone H2AX in response to DNA double-strand breaks JO - J Biol Chem VL - 276 UR - https://doi.org/10.1074/jbc.C100466200 DO - 10.1074/jbc.C100466200 ID - Burma2001 ER - TY - JOUR AU - Wang, H. AU - Wang, M. AU - Wang, H. AU - Bocker, W. AU - Iliakis, G. PY - 2005 DA - 2005// TI - Complex H2AX phosphorylation patterms by multiple kinases including ATM and DNA-PK in human cells exposed to ionizing radiation and treated with kinase inhibitors JO - J Cell Physiol VL - 202 UR - https://doi.org/10.1002/jcp.20141 DO - 10.1002/jcp.20141 ID - Wang2005 ER - TY - JOUR AU - Anderson, L. AU - Henderson, C. AU - Adachi, Y. PY - 2001 DA - 2001// TI - Phosphorylation and rapid relocalization of 53BP1 to nuclear foci upon DNA damage JO - Mol Cell Biol VL - 21 UR - https://doi.org/10.1128/MCB.21.5.1719-1729.2001 DO - 10.1128/MCB.21.5.1719-1729.2001 ID - Anderson2001 ER - TY - JOUR AU - Chanoux, R. A. AU - Yin, B. u. AU - Urtishak, K. A. AU - Asare, A. AU - Bassing, C. H. AU - Brown, E. J. PY - 2009 DA - 2009// TI - ATR and H2AX cooperate in maintaining genome stability under replication stress JO - J Biol Chem VL - 284 UR - https://doi.org/10.1074/jbc.M806739200 DO - 10.1074/jbc.M806739200 ID - Chanoux2009 ER - TY - JOUR AU - Park, E. J. AU - Chan, D. W. AU - Park, J. H. AU - Oettinger, M. A. AU - Kwon, J. PY - 2003 DA - 2003// TI - DNA-PK is activated by nucleosomes and phosphorylated H2AX within the nucleosomes in an acetylation-dependent manner JO - Nucleic Acids Res VL - 31 UR - https://doi.org/10.1093/nar/gkg921 DO - 10.1093/nar/gkg921 ID - Park2003 ER - TY - JOUR AU - Bartkova, J. AU - Bakkenist, C. J. AU - Rajpert-De Meyts, E. AU - Skakkebaek, N. E. AU - Sehested, M. AU - Lukas, J. AU - Kastan, M. B. AU - Bartek, J. PY - 2005 DA - 2005// TI - ATM activation in normal human tissues and testicular cancer JO - Cell Cycle VL - 4 UR - https://doi.org/10.4161/cc.4.6.1742 DO - 10.4161/cc.4.6.1742 ID - Bartkova2005 ER - TY - JOUR AU - Stiff, T. AU - O'Driscoll, M. AU - Rief, N. AU - Iwabuchi, K. AU - Lobrich, M. AU - Jeggo, P. A. PY - 2004 DA - 2004// TI - ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation JO - Cancer Res VL - 64 UR - https://doi.org/10.1158/0008-5472.CAN-03-3207 DO - 10.1158/0008-5472.CAN-03-3207 ID - Stiff2004 ER - TY - JOUR AU - Lavin, M. F. AU - Kozlov, S. PY - 2007 DA - 2007// TI - ATM activation and DNA damage response JO - Cell Cycle VL - 6 UR - https://doi.org/10.4161/cc.6.8.4180 DO - 10.4161/cc.6.8.4180 ID - Lavin2007 ER - TY - JOUR AU - Ward, I. M. AU - Minn, K. AU - Chen, J. PY - 2004 DA - 2004// TI - UV-induced ataxia-telangiectasia-mutated and Rad3-related (ATR) activation requires replication stress JO - J Biol Chem VL - 279 UR - https://doi.org/10.1074/jbc.C300554200 DO - 10.1074/jbc.C300554200 ID - Ward2004 ER - TY - JOUR AU - Mukherjee, B. AU - Kessinger, C. AU - Kobayashi, J. AU - Chen, B. P. C. AU - Chen, D. J. AU - Chatterjee, A. AU - Burma, S. PY - 2006 DA - 2006// TI - DNA-PK phosphorylates histone H2AX during apoptotic DNA fragmentation in mammalian cells JO - DNA Repair (Amst) VL - 5 UR - https://doi.org/10.1016/j.dnarep.2006.01.011 DO - 10.1016/j.dnarep.2006.01.011 ID - Mukherjee2006 ER - TY - JOUR AU - Solier, S. AU - Sordet, O. AU - Kohn, K. W. AU - Pommier, Y. PY - 2009 DA - 2009// TI - Death receptor-induced activation of the Chk2- and histone H2AX-associated DNA damage response pathways JO - Mol Cell Biol VL - 29 UR - https://doi.org/10.1128/MCB.00581-08 DO - 10.1128/MCB.00581-08 ID - Solier2009 ER - TY - JOUR AU - Reitsema, T. AU - Klokov, D. AU - Banath, J. P. AU - Olive, P. L. PY - 2005 DA - 2005// TI - DNA-PK is responsible for enhanced phosphorylation of histone H2AX under hypertonic conditions JO - DNA Repair (Amst) VL - 4 UR - https://doi.org/10.1016/j.dnarep.2005.06.005 DO - 10.1016/j.dnarep.2005.06.005 ID - Reitsema2005 ER - TY - JOUR AU - Shimura, T. AU - Martin, M. M. AU - Torres, M. J. AU - Gu, C. AU - Pluth, J. M. AU - DiBernardi, M. A. AU - McDonald, J. S. AU - Aladjem, M. I. PY - 2007 DA - 2007// TI - DNA-PK is involved in repairing a transient surge of DNA breaks induced by deceleration of DNA replication JO - J Mol Biol VL - 367 UR - https://doi.org/10.1016/j.jmb.2007.01.018 DO - 10.1016/j.jmb.2007.01.018 ID - Shimura2007 ER - TY - JOUR AU - Shao, R. G. AU - Cao, C. X. AU - Zhang, H. AU - Kohn, K. W. AU - Wold, M. S. AU - Pommier, Y. PY - 1999 DA - 1999// TI - Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes JO - The EMBO J VL - 18 UR - https://doi.org/10.1093/emboj/18.5.1397 DO - 10.1093/emboj/18.5.1397 ID - Shao1999 ER - TY - JOUR AU - Koike, M. AU - Sugasawa, J. AU - Yasuda, M. AU - Koike, A. PY - 2008 DA - 2008// TI - Tissue-specific DNA-PK- dependent H2AX phosphorylation and γ-H2AX elimination after X-irradiation in vivo JO - Biochem Biophys Res Commun VL - 376 UR - https://doi.org/10.1016/j.bbrc.2008.08.095 DO - 10.1016/j.bbrc.2008.08.095 ID - Koike2008 ER - TY - JOUR AU - Chowdhury, D. AU - Keogh, M. C. AU - Ishii, H. AU - Peterson, C. L. AU - Buratowski, S. AU - Lieberman, J. PY - 2005 DA - 2005// TI - γ-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repair JO - Mol Cell VL - 20 UR - https://doi.org/10.1016/j.molcel.2005.10.003 DO - 10.1016/j.molcel.2005.10.003 ID - Chowdhury2005 ER - TY - JOUR AU - Chowdhury, D. AU - Xu, X. AU - Zhong, X. AU - Ahmed, F. AU - Zhong, J. AU - Liao, J. AU - Dykxhoorn, D. M. AU - Weinstock, D. M. AU - Pferifer, G. P. AU - Lieberman, J. PY - 2008 DA - 2008// TI - A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication JO - Mol Cell VL - 31 UR - https://doi.org/10.1016/j.molcel.2008.05.016 DO - 10.1016/j.molcel.2008.05.016 ID - Chowdhury2008 ER - TY - JOUR AU - Nakada, S. AU - Chen, G. I. AU - Gingras, A. C. AU - Durocher, D. PY - 2008 DA - 2008// TI - PP4 is a γH2AX phosphatase required for recovery from the DNA damage checkpoint JO - EMBO Rep VL - 9 UR - https://doi.org/10.1038/embor.2008.162 DO - 10.1038/embor.2008.162 ID - Nakada2008 ER - TY - JOUR AU - Bozulic, L. AU - Surucu, B. AU - Hynx, D. AU - Hemmings, B. A. PY - 2008 DA - 2008// TI - PKBa/Akt1 acts downstream of DNA-PK in the DNA double-strand break response and promotes survival JO - Mol Cell VL - 30 UR - https://doi.org/10.1016/j.molcel.2008.02.024 DO - 10.1016/j.molcel.2008.02.024 ID - Bozulic2008 ER - TY - JOUR AU - Feng, J. AU - Park, J. AU - Cron, P. AU - Hess, D. AU - Hemmings, B. A. PY - 2004 DA - 2004// TI - Identification of a PKB/AKT hydrophobic motif ser-473 kinase as DNA-dependent protein kinase JO - J Biol Chem VL - 279 UR - https://doi.org/10.1074/jbc.M406731200 DO - 10.1074/jbc.M406731200 ID - Feng2004 ER - TY - JOUR AU - Goldberg, M. AU - Stucki, M. AU - Falck, J. AU - D'Amours, D. AU - Rahman, D. AU - Pappin, D. PY - 2003 DA - 2003// TI - MDC1 is required for the intra-S-phase DNA damage checkpoint JO - Nature VL - 421 UR - https://doi.org/10.1038/nature01445 DO - 10.1038/nature01445 ID - Goldberg2003 ER - TY - JOUR AU - Kinner, A. AU - Wu, W. AU - Staudt, C. AU - Iliakis, G. PY - 2008 DA - 2008// TI - γ-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin JO - Nucleic Acids Res VL - 36 UR - https://doi.org/10.1093/nar/gkn550 DO - 10.1093/nar/gkn550 ID - Kinner2008 ER - TY - JOUR AU - Stewart, G. S. AU - Wang, B. AU - Bignell, C. R. AU - Taylor, A. M. AU - Elledge, S. J. PY - 2003 DA - 2003// TI - MDC1 is a mediator of the mammalian DNA damage checkpoint JO - Nature VL - 421 UR - https://doi.org/10.1038/nature01446 DO - 10.1038/nature01446 ID - Stewart2003 ER - TY - JOUR AU - Peng, Y. AU - Woods, R. G. AU - Beamish, H. AU - Ye, R. AU - Lees-Miller, S. P. AU - Lavin, M. F. AU - Bedford, J. S. PY - 2005 DA - 2005// TI - Deficiency in the catalytic subunit of DNA-dependent protein kinase causes down-regulation of ATM JO - Cancer Res VL - 65 UR - https://doi.org/10.1158/0008-5472.CAN-04-3451 DO - 10.1158/0008-5472.CAN-04-3451 ID - Peng2005 ER - TY - JOUR AU - Shimura, T. AU - Torres, M. J. AU - Martin, M. M. AU - Rao, V. A. AU - Pommier, Y. AU - Katsura, M. AU - Miyagawa, K. AU - Aladjem, M. I. PY - 2008 DA - 2008// TI - Bloom's syndrome helicase and Mus81 are required to induce transient double-strand DNA breaks in response to DNA replication stress JO - J Mol Biol VL - 375 UR - https://doi.org/10.1016/j.jmb.2007.11.006 DO - 10.1016/j.jmb.2007.11.006 ID - Shimura2008 ER - TY - JOUR AU - Huang, X. AU - Tanaka, T. AU - Kurose, A. AU - Traganos, F. AU - Darzynkiewicz, Z. PY - 2006 DA - 2006// TI - Constitutive histone H2AX phosphorylation on Ser-139 in cells untreated by genotoxic agents is cell-cycle phase specific and attenuated by scavenging reactive oxygen species JO - Int J Oncol VL - 29 ID - Huang2006 ER - TY - JOUR AU - Kurise, A. AU - Tanaka, T. AU - Huang, X. AU - Traganos, F. AU - Darzynkiewicz, Z. PY - 2006 DA - 2006// TI - Synchronization in the cell cycle by inhibitors of DNA replication induces histone H2AX phosphorylation: an indication of DNA damage JO - Cell Prolif VL - 39 UR - https://doi.org/10.1111/j.1365-2184.2006.00380.x DO - 10.1111/j.1365-2184.2006.00380.x ID - Kurise2006 ER - TY - JOUR AU - Ichijima, Y. AU - Sakasai, R. AU - Okita, N. AU - Asahina, K. AU - Mizutani, S. AU - Teraoka, H. PY - 2005 DA - 2005// TI - Phosphorylation of histone H2AX at M phase in human cells without DNA damage response JO - Biochem Biophys Res Commun VL - 336 UR - https://doi.org/10.1016/j.bbrc.2005.08.164 DO - 10.1016/j.bbrc.2005.08.164 ID - Ichijima2005 ER - TY - JOUR AU - Alessi, D. R. AU - James, S. R. AU - Downes, C. P. AU - Holmes, A. B. AU - Gaffney, P. R. AU - Reese, C. B. AU - Cohen, P. PY - 1997 DA - 1997// TI - Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha JO - Curr Biol VL - 7 UR - https://doi.org/10.1016/S0960-9822(06)00122-9 DO - 10.1016/S0960-9822(06)00122-9 ID - Alessi1997 ER - TY - JOUR AU - Sarbassov, D. D. AU - Guertin, D. A. AU - Ali, S. M. AU - Sabatini, D. M. PY - 2005 DA - 2005// TI - Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex JO - Science VL - 307 UR - https://doi.org/10.1126/science.1106148 DO - 10.1126/science.1106148 ID - Sarbassov2005 ER - TY - JOUR AU - Park, J. AU - Feng, J. AU - Li, Y. AU - Hammarsten, O. AU - Brazil, D. P. AU - Hemmings, B. A. PY - 2009 DA - 2009// TI - DNA-dependent protein kinase-mediated phosphorylation of protein kinase B requires a specific recognition sequence in the C-terminal hydrophobic motif JO - J Biol Chem VL - 284 UR - https://doi.org/10.1074/jbc.C800210200 DO - 10.1074/jbc.C800210200 ID - Park2009 ER - TY - JOUR AU - Cross, D. A. AU - Alessi, D. R. AU - Cohen, P. AU - Andjelkovich, M. AU - Hemmings, B. A. PY - 1995 DA - 1995// TI - Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B JO - Nature VL - 378 UR - https://doi.org/10.1038/378785a0 DO - 10.1038/378785a0 ID - Cross1995 ER - TY - JOUR AU - An, J. AU - Yang, D. Y. AU - Xu, Q. Z. AU - Zhang, S. M. AU - Huo, Y. Y. AU - Shang, Z. F. AU - Wang, Y. AU - Wu, D. C. AU - Zhou, P. K. PY - 2008 DA - 2008// TI - DNA-dependent protein kinase catalytic subunit modulates the stability of c-Myc oncoprotein JO - Mol Cancer VL - 7 UR - https://doi.org/10.1186/1476-4598-7-32 DO - 10.1186/1476-4598-7-32 ID - An2008 ER -