Figure 4

Comparison of the transcriptome effects of TAF6δ with TAF9 and TAF9b. (A) A heat map representation of changes in expression of 800 mRNAs that could be mapped from the published data resulting from depletion of TAF9 or TAF9b [16] to the TAF6δ-dependent transcriptome signature shows the global comparison of their respective transcriptome profiles. The red gradient indicates positive, and the blue gradient negative fold changes in expression. (B) A Venn diagram representation of the transcriptome comparison shows the relationship between genes significantly regulated by TAF6δ, TAF9 and TAF9b. 803 probes were mapped onto the 961 probe TAF6δ signature. (C) Overrepresentation of the "p53 feedback loop 2" gene ontology pathway is common to the TAF6δ, TAF9 and TAF9b signatures. Pathway analysis was performed as described in Materials and Methods for genes significantly regulated by both TAF6δ and TAF9 (left), by all of TAF6δ, TAF9 and TAF9b (right). P-values for overrepresentation are shown in the table. (D) Overrepresentation of the angiogenesis gene ontology pathway is common to the TAF6δ, TAF9 and TAF9b transcription signatures. Pathway analysis as in (C). (E) Microarray recorded gene expression changes for examples of genes similarly regulated by TAF6δ, TAF9 and TAF9b are shown. Error bars indicate standard deviations.