Figure 2

Pathway analysis of the TAF6δ transcriptome signature. (A) Specific cellular pathways are statistically significantly (P < 0.05) overrepresented in the TAF6δ-regulated transcriptome. "Count" indicates the number of probes within the dataset that corresponds to a given gene ontology pathway, "Expect." is the number of probes one would expect to find for a given pathway in a random dataset of identical size. (B) Interconnectivity analysis reveals statistically significant overrepresentation of shared genes between TAF6δ-affected cellular pathways. Red and orange indicate highly significant (P < 0.05) and significant (P < 0.10) overrepresentation of shared regulated genes, light grey indicates present links of low statistical significance between the pathways from B. (C) Interconnectivity between overrepresented pathways (highlighted in color and listed at right) is shown in a network representation generated using Pajek software [27].