Table 1 cDNA clones predicted to encode protease family proteins
From: Preliminary molecular characterization of the human pathogen Angiostrongylus cantonensis
Clone No. | N | Homologous gene [organism] | Protease family | Functions |
|---|---|---|---|---|
0009D10 | 1 | Serine protease pcp-1 precursor 1 [C. elegans] | Serine protease | Facilitates penetration and migration [38–40]; Immune evasion [41, 43]; Lysosomal protection |
0005E12 | 3 | Cathepsin A [Monodelphis domestica] | Â | Â |
00012B11 | 1 | Cysteine proteinase [Haemonchus contortus] | Â | Â |
0007D03 | 1 | Cathepsin B-like cysteine protease 2 [Parelaphostrongylus tenuis] | Â | Â |
0014F02 | 2 | Cathepsin B-like cysteine protease 1 [P. tenuis] | Cysteine protease | Degradation of hemoglobin and serum albumin [36]; Iron acquisition; Larva molting; Degradation of phagocytosed material; Immune evasion [44, 45] |
0005F12 | 4 | Cathepsin L 1 [Dictyocaulus viviparus] | Â | Â |
00012F09 | 10 | CathePsin Z family member (cpz-1) [C. elegans] | Â | Â |
15G12 | 1 | Aspartyl protease family member (asp-1) [C. elegans] | Â | [42] |
0006G04 | 2 | Aspartyl protease protein 6 [C. elegans] | Aspartyl protease | Digestion of hemoglobin serum protein [35, 37]; Intestinal digestion and tissue degradation; Initiates a catabolic pathway; Immune evasion [42] |
00010A09 | 3 | Aspartyl protease family member (asp-2) [C. elegans] | Â | Â |
16B10 | 14 | Cathepsin D-like aspartic protease [Ancylostoma ceylanicum] | Â | Â |