Figure 6
Mapping of Cdc1 mutants to the structure of human p50•p66 N complex. The secondary structure elements are colour-coded as follows: α-helices, β-strands and coils are red, yellow and green in p50, and cyan, magenta and light pink in p66N. The sites of pentapeptide insertions and amino acid substitutions are highlighted by double and single grey spheres, respectively. In panel B the blue sphere indicates the position of Gln347. The labels in magenta, green and grey correspond to non-functional, partially functional and fully functional pentapeptide insertions or amino acid substitutions. The disordered region d1 was modelled for panels A, C, and D. The positions of disordered regions d1-d4 are drawn by dotted lines in panel B. The figure was prepared with PyMol software (Delano Scientific) using the coordinates of p50•p66N complex (Protein Data Bank with accession code 3E0J) [10].