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Table 1 Hypertension candidate genes associated with antisense transcripts.

From: Natural antisense transcript of natriuretic peptide precursor A (NPPA): structural organization and modulation of NPPA expression

Gene

Antisense overlap*

Antisense mRNA/ESTs§

Antisense ORF

ADD3(adducin 3)

chr10:111,746,098-111,885,313

2 exons, both 5' UTR

U92992 (total 17 ESTs)

3 exons, 99 aa

NPPA(natriuretic peptide precursor A)

chr1:11,828,363-11,830,422

3 exons

BU732528 (total 12 ESTs)

1 exon, 121 aa

ATP1A1(Na+/K+ -ATPase alpha 1 subunit)

chr1:116,717,359-116,748,919

3 coding exons

AK309389 (total 27 ESTs)

 

NPR2(natriuretic peptide receptor B)

chr9:35,782,406-35,799,728

1 exon (coding and 3' UTR)

SPAG8 (total 37 ESTs)

8 exons, 501 aa

CYP17A1(cytochrome P450, family 17)

chr10:104,580,278-104,587,280

3 coding exons

BX100578 (total 6 ESTs)

 

ACSM3(acyl-coenzyme A synthetase)

chr16:20,682,813-20,715,980

1 coding exon

EXOD1 (total 49 ESTs)

11 exons, 328 aa

SLC14A2(solute carrier family 14, member 2)

chr18:41,046,958-41,517,058

1 noncoding 5' UTR exon

AK126075 (total 12 ESTs)

 
  1. * Number of sense gene exons involved in sense-antisense complementarity. § A gene symbol or a GenBank accession of a representative EST or mRNA and a total number of ESTs in antisense cluster. ORF – open reading frame (only ORFs larger than 90 aa are shown), UTR – untranslated region, aa – amino acids.