Skip to main content
Figure 1 | BMC Molecular Biology

Figure 1

From: Influence of vector design and host cell on the mechanism of recombination and emergence of mutant subpopulations of replicating retroviral vectors

Figure 1

MLV-based RCR vectors. Moloney-MLV-based (ACE-GFP, ACEU3-GFP, white vector backbone) and Akv MLV-based (Akv4070AeGFP, AkvB4070AeGFP, grey vector backbone) vectors harbouring an IRES-eGFP transgene cassette either immediately downstream of the MLV 4070A env gene or inserted in the U3 region of the 3' LTR. A single amino acid was altered (Glu to Arg indicated by an asterisk) in the N-tropic vector Akv4070AeGFP to generate the B-tropic vector AkvB4070AeGFP, which can efficiently infect human cells.

Back to article page

BMC Molecular Biology

ISSN: 1471-2199

Contact us